This paper presents a microfluidic device specially designed for DNA tile self-assembly. The DNA tile is one of the most promising building blocks for complex nanostructure, which can be used as a molecular computer or a scaffold for functional molecular machineries. In order to build desired nanostructure, it is necessary to realize errorless self-assembly under thermal fluctuation. We propose a method to directly control environmental parameters of DNA self-assembly such as concentration of each monomer tile and temperature in the reaction chamber by using a microfluidic device. The proposed device is driven by a capillary pump and has an open reaction chamber which enables real-time observation by AFM. Results of preliminary experiments to evaluate performance of the device will be reported. © Springer-Verlag Berlin Heidelberg 2006.
CITATION STYLE
Somei, K., Kaneda, S., Fujii, T., & Murata, S. (2006). A microfluidic device for DNA tile self-assembly. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 3892 LNCS, pp. 325–335). https://doi.org/10.1007/11753681_25
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