In ischemia the cytosol of cardiomyocytes acidifies; this is reversed upon reperfusion. One of the major pH(i)-regulating transport systems involved is the Na+/H+ exchanger. Inhibitors of the Na+/H+ exchanger have been found to more effectively protect ischemic-reperfused myocardium when administered before and during ischemia than during reperfusion alone. It has been hypothesized that the protection provided by pre-ischemic administration is due to a reduction in Na+ and secondary Ca2+ influx. Under reperfusion conditions Na+/H+ exchange inhibition also seems protective since it prolongs intracellular acidosis which can prevent hypercontracture. In detail, however, the mechanisms by which Na+/H+ exchange inhibition provides protection in ischemic-reperfused myocardium are still not fully identified.
CITATION STYLE
Piper, H. M., Balser, C., Ladilov, Y. V., Schäfer, M., Siegmund, B., Ruiz-Meana, M., & Garcia-Dorado, D. (1996). The role of Na+/H+ exchange in ischemia-reperfusion. Basic Research in Cardiology, 91(3), 191–202. https://doi.org/10.1007/BF00788905
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