Increased risk of breast and uterine cancer among women with ovarian granulosa cell tumors

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Abstract

Background/Aim: We evaluated the incidence of uterine and breast cancer among women diagnosed with granulosa cell tumors (GCTs) of the ovary. Patients and Methods: The US Surveillance, Epidemiology, and End Results (SEER) database was accessed and patients diagnosed with a GCT and had a known follow-up between 1973-2014 were identified. Personal tumor history was extracted and patients with a previous or subsequent malignant breast or uterine tumor were identified. The expected incidence of breast and uterine cancer was calculated based on the U.S age-specific rate of breast and uterine cancer per 100,000 women. Standardized incidence ratio (SIR) with 95% confidence intervals (95% CI) were calculated for each tumor. Results: A total of 1908 cases of GCT were identified. Seventy- nine (4.14%) and 53 (2.78%) patients were diagnosed with a malignant breast and uterine malignancy. The cumulative expected number of malignant breast and uterine tumors was 27 (1.41%) and 6 (0.31%), respectively. The calculated SIR for breast and uterine malignancies was 2.96 (95%CI=2.34, 3.68) and 8.83 (95%CI=6.61, 11.56), respectively. Conclusion: An increased incidence of breast and uterine malignancies among patients diagnosed with GCTs was observed.

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Nasioudis, D., Wilson, E., Mastroyannis, S. A., Sisti, G., Haggerty, A. F., Ko, E. M., & Latif, N. A. (2019). Increased risk of breast and uterine cancer among women with ovarian granulosa cell tumors. Anticancer Research, 39(9), 4971–4975. https://doi.org/10.21873/anticanres.13686

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