Outcome of Adults with Leptospirosis and Renal Failure Treated with Pulse Immunosuppression

Abstract

Introduction: Leptospirosis presenting with renal failure is often accompanied by pulmonary hemorrhage and carries a high mortality despite standard therapy. There is increasing evidence for an immunologic mechanism mediating both these complications hence methylprednisolone and cyclophosphamide were adapted in the treatment protocol to improve overall outcome.