A continuous flow process for the synthesis of trifluoromethylthioethers is reported. The palladium-catalyzed C-H trifluoromethylthiolation of amides derived from the 8-aminoquinoline using N-[(trifluoromethyl)thio]phthalimide produced the desired products in moderate to good yields with a residence time of 20 min. In comparison with the batch process, the reaction time was decreased by a factor of 100 to 200, demonstrating the positive effect of continuous flow processes for this type of reaction.
CITATION STYLE
Bouchard, A., Kairouz, V., Manneveau, M., Xiong, H. Y., Besset, T., Pannecoucke, X., & Lebel, H. (2019). Continuous flow palladium-catalyzed trifluoromethylthiolation of C-H bonds. Journal of Flow Chemistry, 9(1), 9–12. https://doi.org/10.1007/s41981-018-0023-4
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