Perceiving signals, building networks, reprogramming germ cell fate

6Citations
Citations of this article
36Readers
Mendeley users who have this article in their library.

Abstract

Germ cell development is a step-wise process that ensures the progression of the life cycle due to their unique ability to transmit their genome from one generation to the next. In the mouse, the precursors of germ cells, the Primordial Germ Cells (PGCs), arise at the onset of gastru-lation. Here we discuss how PGCs acquire their fate in the epiblast and outline their development until their arrival into the gonads. Male germ cell tumors (GCTs) have a similar gene expression pattern to that of fetal germ cells and to pluripotent cells, suggesting that GCT originate from an alteration of gonocyte normal development. We evaluate coincidences and differences in germ cell development in mouse and humans and on this basis, we speculate future research perspectives. © 2013 UBC Press.

References Powered by Scopus

Vertebrate protein glycosylation: Diversity, synthesis and function

1338Citations
N/AReaders
Get full text

Bmp4 is required for the generation of primordial germ cells in the mouse embryo

1111Citations
N/AReaders
Get full text

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells

1087Citations
N/AReaders
Get full text

Cited by Powered by Scopus

SOX17 is a critical specifier of human primordial germ cell fate

653Citations
N/AReaders
Get full text

Global transcriptional repression: An initial and essential step for Plasmodium sexual development

80Citations
N/AReaders
Get full text

Pathogenesis of germ cell neoplasia in testicular dysgenesis and disorders of sex development

54Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Barrios, F., Irie, N., & Surani, M. A. (2013). Perceiving signals, building networks, reprogramming germ cell fate. International Journal of Developmental Biology, 57(2–4), 123–132. https://doi.org/10.1387/ijdb.130132fb

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 17

53%

Researcher 9

28%

Professor / Associate Prof. 5

16%

Lecturer / Post doc 1

3%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 15

47%

Biochemistry, Genetics and Molecular Bi... 14

44%

Medicine and Dentistry 2

6%

Design 1

3%

Save time finding and organizing research with Mendeley

Sign up for free