Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study

9Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.

Abstract

Lead causes damage to the whole body by inducing oxidative stress. This includes the testis, in which spermatogenesis is affected. Etlingera elatior, a consumable plant that is being extensively studied for its high anti-oxidant properties, was tested against the effect of lead acetate in experimental rats. Rats were divided into groups consisting of a control, lead acetate only, Etlingera elatior treatment only, concurrent treatment of lead acetate and Etlingera elatior, post-treatment of lead acetate followed by Etlingera elatior and preventive group of Etlingera elatior followed by lead acetate. The substances were administered for 14 days and the effects were measured by protein carbonyl content (PCC), superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity in the testis, as well as the testosterone level in the serum. Histological changes in the testis were also observed. Results showed that Etlingera elatior induced a significant reduction in the testis PCC activity, while at the same time it significantly increased the activities of SOD and GPx in the testis, and the testosterone level in the serum. Etlingera elatior also improved the histology of the testis when compared to the lead acetate-treated group. On the whole, Etlingera elatior is effective against oxidative damage caused by lead acetate in the testis.

Cite

CITATION STYLE

APA

Haw, K. Y., Chakravarthi, S., Haleagrahara, N., & Rao, M. (2012). Effects of Etlingera elatior extracts on lead acetate-induced testicular damage: A morphological and biochemical study. Experimental and Therapeutic Medicine, 3(1), 99–104. https://doi.org/10.3892/etm.2011.355

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free