Drug-Target Interaction Prediction Based on Multisource Information Weighted Fusion

Abstract

Recently, in most existing studies, it is assumed that there are no interaction relationships between drugs and targets with unknown interactions. However, unknown interactions mean the relationships between drugs and targets have just not been confirmed. In this paper, samples for which the relationship between drugs and targets has not been determined are considered unlabeled. A weighted fusion method of multisource information is proposed to screen drug-target interactions. Firstly, some drug-target pairs which may have interactions are selected. Secondly, the selected drug-target pairs are added to the positive samples, which are regarded as known to have interaction relationships, and the original interaction relationship matrix is revised. Finally, the revised datasets are used to predict the interaction derived from the bipartite local model with neighbor-based interaction profile inferring (BLM-NII). Experiments demonstrate that the proposed method has greatly improved specificity, sensitivity, precision, and accuracy compared with the BLM-NII method. In addition, compared with several state-of-the-art methods, the area under the receiver operating characteristic curve (AUC) and the area under the precision-recall curve (AUPR) of the proposed method are excellent.