Interaction of nonsense suppressor tRNAs and codon nonsense mutations or termination codons

Abstract

Codon nonsense mutations include amber, ochre, or opal mutations according to termination codon con-sisting of three types (TAG, TAA and TGA). Codon nonsense mutations are also divided into natural and artificial mutations. We discussed the interaction of codon nonsense mutations and suppressor tRNAs in vitro and in vivo. Nonsense suppressions do not only happen in prokaryotes but also in eukaryotes. Mean-while, the misreading of termination codon and in-corporation of nonnatural amino acids into proteins are also introduced.