Prediction of the lipophilicity of nine new synthesized selenazoly and three aroylhydrazinoselenazoles derivatives by reversed-phase high performance thin-layer chromatography

Abstract

Using reversed-phase high-performance thin-layer chromatography and a methanolwater mixture as the mobile phase, the lipophilicity of 12 new synthesized derivatives is studied. The first eight compounds have as a basic chemical structure arylidenhydrazino-selenazoles, and the second group of the three compounds belongs to aroylhydrazinoselenazoles. The linear correlation between RMw and the methanolwater ratios showed high values for the correlation coefficient. The chromatographic hydrophobic index is determined by using the ratio RMw/S, and the obtained values ranged between 99 and 73. A good linear correlation is obtained between RMw and the slope. The log P values are calculated using ACD/Labs Software. The matrices are formed with RMw and log P and are subjected to a principal component analysis (PCA). The best way to extract information from PCA is graphically, by plotting the obtained matrices. By analyzing the scores, the compounds can be grouped as follows: a group containing nine compounds, and a second one containing three compounds. Each group of compounds has the same basic chemical structure. © 2012 The Author.