Crystal structure of benzocaine-A local anaesthetic

Abstract

The structure of the local anaesthetic benzocaine was solved by direct methods and refined to an R of 0·12 for 531 observed reflections. The packing of the molecule is stabilised by N-H ... O hydrogen-bonds (2-97 Â). The alkyl chain attached to the benzene ring is in trans-trans conformation. The benzoic moiety shows a quinonoid character as found in some other local anaesthetics. © 1987 Indian Academy of Sciences.