A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAßN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations.
CITATION STYLE
Manageiro, V., Félix, D., Jones-Dias, D., Sampaio, D. A., Vieira, L., Sancho, L., … Caniça, M. (2017). Genetic background and expression of the new qepa4 gene variant recovered in clinical TEM-1- and CMY-2-producing Escherichia coli. Frontiers in Microbiology, 8(OCT). https://doi.org/10.3389/fmicb.2017.01899
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