Genetic background and expression of the new qepa4 gene variant recovered in clinical TEM-1- and CMY-2-producing Escherichia coli

8Citations
Citations of this article
19Readers
Mendeley users who have this article in their library.

Abstract

A new QepA4 variant was detected in an O86:H28 ST156-fimH38 Escherichia coli, showing a multidrug-resistance phenotype. PAßN inhibition of qepA4-harboring transconjugant resulted in increase of nalidixic acid accumulation. The qepA4 and catA1 genes were clustered in a 26.0-kp contig matching an IncF-type plasmid, and containing a Tn21-type transposon with multiple mobile genetic elements. This QepA variant is worrisome because these determinants might facilitate the selection of higher-level resistance mutants, playing a role in the development of resistance, and/or confer higher-level resistance to fluoroquinolones in association with chromosomal mutations.

Cite

CITATION STYLE

APA

Manageiro, V., Félix, D., Jones-Dias, D., Sampaio, D. A., Vieira, L., Sancho, L., … Caniça, M. (2017). Genetic background and expression of the new qepa4 gene variant recovered in clinical TEM-1- and CMY-2-producing Escherichia coli. Frontiers in Microbiology, 8(OCT). https://doi.org/10.3389/fmicb.2017.01899

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free