AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity. © 2011 Elsevier Inc.
Mair, W., Steffen, K. K., & Dillin, A. (2011, September 16). SIP-ing the elixir of youth. Cell. Cell Press. https://doi.org/10.1016/j.cell.2011.08.026