Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells

101Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Sodium cromoglycate and nedocromil sodium produced a dose dependent inhibition of histamine secretion from human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymatic dissociation of lung parenchyma. Both compounds were significantly more active against the lavage cells than against the dispersed lung cells, and nedocromil sodium was an order of magnitude more effective than sodium cromoglycate against both cell types. Tachyphylaxis was observed with the parenchymal cells but not with the lavage cells. Nedocromil sodium and sodium cromoglycate also inhibited histamine release from the lavage cells of patients with sarcoidosis and extrinsic asthma.

Cite

CITATION STYLE

APA

Leung, K. B. P., Flint, K. C., Brostoff, J., Hudspith, B. N., Mci Johnson, N., Lau, H. Y. A., … Pearce, F. L. (1988). Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. Thorax, 43(10), 756–761. https://doi.org/10.1136/thx.43.10.756

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free