BLAT2DOLite: An Online System for Identifying Significant Relationships between Genetic Sequences and Diseases

Abstract

The significantly related diseases of sequences could play an important role in understanding the functions of these sequences. In this paper, we introduced BLAT2DOLite, an online system for annotating human genes and diseases and identifying the significant relationships between sequences and diseases. Currently, BLAT2DOLite integrates Entrez Gene database and Disease Ontology Lite (DOLite), which contain loci of gene and relationships between genes and diseases. It utilizes hypergeometric test to calculate P-values between genes and diseases of DOLite. The system can be accessed from: http://123.59.132. 21:8080/BLAT2DOLite. The corresponding web service is described in: http://123.59.132. 21:8080/BLAT2DOLite/BLAT2DOLiteIDMappingPort?wsdl.