Association of Serum vitamin D levels, Psoriasis and the Effect of Oral D supplementation on Clinical improvement of Disease

Abstract

Background: Psoriasis is a chronic inflammatory skin disease mediated by the immune system. Hyper-proliferation with incomplete differentiation of epidermal keratinocytes and decreased keratinocyte apoptosis characterize psoriasis lesions. A role in the pathogenesis of various skin diseases for vitamin D includes psoriasis, were reported. Physiologically speaking, the active form and receptor of vitamin D regulate keratinocyte differentiation and proliferation, cutaneous immune system balance, and the apoptosis process. Aims: Evaluate the serum levels of vitamin D in psoriatic patients and to investigate the beneficial effect of oral D supplementation in the treatment of this disease. Subjects and method: This Case study included fifty-eight (58) Iraqi patients with Psoriasis and undergoing biologic therapy who were recruited from the Center of Dermatology and Venereology, Medical city, during the period from September 2019 to February 2020. IL-17 A and hs-CRP were measured in the patients’ serum by Enzyme-Linked Immunosorbent Assay technique Whereas, serum 1,25 (OH) D was measured by using Cobas e 411 analyzers. [PASI] Score, [BMI], [WC], and percentage of sun exposure were be evaluated and reported to be correlated with blood measurements. Results: The mean (±SD) value of serum 25OHVD levels of the placebo group was significantly higher compared to that of the oral vitamin supplement group (P=0.0001) before the supplement. The mean value of serum 25OHVD levels of group vitamin D supplement (after) was significantly increased when compared with that of (before) (P <0.0001) after three months of follow up of VD supplementation. Conclusion: Iraqi psoriatic patients suffer from vitamin D deficiency. An appropriate oral dose of vitamin D supplements can raise vitamin level in the serum to a normal value and, at the same time, be used as adjuvant therapy.