Sesquiterpenoids from the herb of Leonurus japonicus

Abstract

Two new sesquiterpenoids, (-)-(1S*,2S*, 3R*)-3-ethoxycupar-5-ene-1,2-diol (1) and (-)-(1S *,4S*,9S*)-1,9-epoxybisabola- 2,10-diene-4-ol (2), along with six known compounds 3-8, were isolated from the EtOH extract of the herb of Leonurus japonicus. Their structures were elucidated by physical and spectroscopic analysis. In the in vitro assays, compounds 7 and 8 showed obvious antibacterial activity against several bacteria strains, while compound 3 significantly inhibited abnormal increase of platelet aggregation induced by ADP. © 1996-2013 MDPI AG (Basel, Switzerland).