Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats

53Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.

Author supplied keywords

Cite

CITATION STYLE

APA

Baghcheghi, Y., Hosseini, M., Beheshti, F., Salmani, H., & Anaeigoudari, A. (2018). Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats. Arquivos de Neuro-Psiquiatria, 76(1), 32–40. https://doi.org/10.1590/0004-282x20170182

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free