Abstract
Disintegrins represent a family of polypeptides released in the venoms of Viperidae and Crotalidae snakes (vipers and rattlesnakes) by the proteolytic processing of PII Zn2+-metalloproteinases or synthesized from short-coding mRNAs. Disintegrins selectively block the function of β1 and β3 integrin receptors. This review summarizes our current view and hypotheses on the emergence and on the structural and functional diversification of disintegrins.
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CITATION STYLE
Calvete, J. J. (2011). Brief history and molecular determinants of snake venom disintegrin evolution. In Toxins and Hemostasis: From Bench to Bedside (pp. 285–300). Springer Netherlands. https://doi.org/10.1007/978-90-481-9295-3_18
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