Nonlinear Models and Regression

  • Bonate P
N/ACitations
Citations of this article
18Readers
Mendeley users who have this article in their library.
Get full text

Abstract

A model is nonlinear if any of the partial derivatives with respect to any of the model parameters are dependent on any other model parameter or if any of the derivatives do not exist or are discontinuous. This chapter expands on the previous chapter and introduces nonlinear regression within a least squares (NLS) and maximum likelihood framework. The concepts of minima, both local and global, and the gradient and Hessian are introduced and provide a basis for NLS algorithm selection. Ill-conditioning and its role in model instability are prominently discussed, as are influence diagnostics for the nonlinear problem and how to use prior information to obtain better model parameter estimates.

Cite

CITATION STYLE

APA

Bonate, P. L. (2011). Nonlinear Models and Regression. In Pharmacokinetic-Pharmacodynamic Modeling and Simulation (pp. 101–130). Springer US. https://doi.org/10.1007/978-1-4419-9485-1_3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free