Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study

5Citations
Citations of this article
16Readers
Mendeley users who have this article in their library.

Abstract

Aim: The aim of the study was to evaluate the changes in central vascular inflammation measured by FDG PET and myocardial blood flow reserve (MFR) determined by 82Rb PET following therapy with biologic agents for 6 months in patients with psoriatic arthritis (PsA) and/or cutaneous psoriasis (PsO) (group 1) and compare with PsO subjects receiving non-biologic therapy (group 2) and controls (group 3). Methods and Results: Target-to-background ratio (TBR) by FDG PET in the most diseased segment of the ascending aorta (TBRmax) was measured to assess vascular inflammation. 82Rb PET studies were used to assess changes in left ventricular MFR. A total of 34 participants were enrolled in the study (11 in group 1, 13 in group 2, and 10 controls). A significant drop in the thoracic aorta uptake was observed in the biologic-treated group (ΔTBRmax: − .46 ±.55) compared to the PsO group treated with non-biologic therapy (ΔTBRmax:.23 ±.67). Those showing response to biologic agents maintained MFR compared to who showed no response. Conclusion: In a cohort of psoriasis patients treated with biologics, FDG uptake in the thoracic aorta decreased over the study period. Patients who demonstrated a significant anti-inflammatory response on FDG PET imaging maintained their MFR compared to non-responders.

References Powered by Scopus

Classification criteria for psoriatic arthritis: Development of new criteria from a large international study

3011Citations
N/AReaders
Get full text

Risk of myocardial infarction in patients with psoriasis

1652Citations
N/AReaders
Get full text

Imaging atherosclerotic plaque inflammation with [<sup>18</sup>F]-fluorodeoxyglucose positron emission tomography

1112Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Managing psoriatic arthritis in different clinical scenarios

3Citations
N/AReaders
Get full text

The Canadian Study of Arterial Inflammation in Patients with Diabetes and Recent Vascular Events, Evaluation of Colchicine Effectiveness (CADENCE): protocol for a randomised, double-blind, placebo-controlled trial

2Citations
N/AReaders
Get full text

Atherosclerosis as the Damocles' sword of human evolution: insights from nonhuman ape-like primates, ancient human remains, and isolated modern human populations

1Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Boczar, K. E., Beanlands, R. S., Glassman, S. J., Wang, J., Zeng, W., deKemp, R. A., … Dwivedi, G. (2023). Anti-inflammatory effect of biologic therapy in patients with psoriatic disease: A prospective cohort FDG PET study. Journal of Nuclear Cardiology, 30(4), 1642–1652. https://doi.org/10.1007/s12350-023-03204-8

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 2

67%

Lecturer / Post doc 1

33%

Readers' Discipline

Tooltip

Medicine and Dentistry 6

86%

Pharmacology, Toxicology and Pharmaceut... 1

14%

Article Metrics

Tooltip
Mentions
News Mentions: 1

Save time finding and organizing research with Mendeley

Sign up for free