Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus

  • Rojas M
  • Rodríguez Y
  • Leon K
  • et al.
N/ACitations
Citations of this article
92Readers
Mendeley users who have this article in their library.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by a breakdown in immune tolerance that induces an attack on normal tissues by the immune system. The dysfunction within both the innate and adaptive immune systems increases cytokine production, B lymphocytic overproduction of autoantibodies, and T lymphocyte activity. Cytokines and inflammatory mediators have been associated with several clinical endpoints, including the activity of disease and outcomes. In fact, some of them have been associated with different clinical subphenotypes (e.g., lupus nephritis), suggesting their role as biomarkers, and, in some cases, therapeutic targets. Thus, knowledge of the pathophysiological processes associated with the development of SLE could aid in setting up better diagnostic and therapeutic approaches to reduce the high burden of disease, and thus improve quality of life and outcomes. Herein, the authors have compiled a concise review of the clinically relevant cytokines and inflammatory mediators associated with SLE and its manifestations.

Cite

CITATION STYLE

APA

Rojas, M., Rodríguez, Y., Leon, K. J., Pacheco, Y., Acosta-Ampudia, Y., Monsalve, D. M., … Anaya, J.-M. (2018). Cytokines and Inflammatory Mediators in Systemic Lupus Erythematosus. EMJ Rheumatology, 83–92. https://doi.org/10.33590/emjrheumatol/10311457

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free