Sargassum polycystum Decoct Improves Hyperglycemic Symptoms on the Type 2 Diabetic

Abstract

Sargassum polycystum is one type of brown algae that contains many bioactive compounds, including polyphenols. This compound is known to be anti-hyperglycemic that beneficial for the control of blood glucose and diabetic symptoms in diabetics. Symptoms caused by hyperglycemia are weight loss, polyphagia, polyuria, and polydipsia. Polyphenols are compounds that dissolve quickly and are easily obtained by decoction. The purpose of this study was to examine S. polycystum decoct for improvement in diabetes symptom in type 2 diabetes mellitus rats. This study was carried out at the Laboratory for Physiology and Biomedicine on the Medical Faculty of the Universitas Brawijaya. This study consisted of 7 treatments: negative control, negative control + metformin, diabetes control, diabetes + metformin, diabetic rats + 0.5 mL of decoct, diabetic rats + 1 mL of decoct, and diabetic rats + 1.5 mL of decoct, respectively. Blood glucose and diabetes symptom were observed at the end of the study. The results showed that the diabetic rat group suffered from hyperglycemia and diabetes symptoms. Treatment of S. polycystum decocts on type 2 diabetes mellitus rats decreased blood sugar levels and improved diabetes symptom. However, the results were not as optimal as in diabetic animals treated with metformin. The conclusion is that S. polycystum decoct can reduce hyperglycemia and diabetes symptoms in rats with type 2 diabetes mellitus.