Influence of milk on absorption of NM441, a prodrug type of quinolone antibiotic

Abstract

The influence of milk on absorption of NM441, a new prodrug type of quinolone antibiotic, was investigated in 6 healthy male volunteers. Serum maximum concentrations (C(max)) of NM394 (an active form of NM441) were 1.43±0.27 μg/ml (Mean±SD) and 1.0±0.26 μg/ml, and AUC(0-∞) were 7.60 ± 1.47 μg · h/ml and 5.19 ± 1.72 μg · h/ml in the administration of NM441 (200mg equivalent to NM394) with 200ml of water and milk, respectively, showing about 30% of significant decreases in administration with milk. The accumulated urinary excretion rates by 24h after administration were 43.9 ± 5.8% and 30.8 ± 5.4% in administration with water and milk, respectively, showing also about 30% of decreases in administration with milk. There were no large differences in T(max) and T( 1/2 ). From the above results, it was confirmed the administration of NM441 with milk decreases the absorption of this drug.