Causes of Neurodegeneration in Diabetes: Possible Culprits and Therapeutic Targets

Abstract

Diabetes, a global epidemic, has been shown to be linked to incidence of neurodegenerative disorders. Hyperglycemia is linked to cognitive decline, Alzheimer’s disease, dementia and neurodegeneration in general. The mechanisms of diabetes/hyperglycemia-mediated neurodegeneration are largely unknown. This review sheds light on mechanisms that could possibly lead to hyperglycemia-mediated neurodenegeration namely apoptosis, oxidative stress, AGE, etc. Additionally relevant therapeutic strategies are also discussed.