Abstract
The bovine leukemia virus (BLV) envelope gene encoding extracellular glycoprotein gp51 and transmembrane glycoprotein gp30 was cloned into a vehicle expression vector under the human cytomegalovirus (CMV) intermediate early promoter. The intramuscular injection of this plasmid vector generated a cellular immune response. Seven out of ten cows vaccinated with the DNA construct resisted a drastic challenge (500 BLV-infected lymphocytes as an infectious dose).
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Brillowska, A., Da̧browski, S., Rułka, J., Kubiś, P., Buzała, E., & Kur, J. (1999). Protection of cattle against bovine leukemia virus (BLV) infection could be attained by DNA vaccination. Acta Biochimica Polonica, 46(4), 971–976. https://doi.org/10.18388/abp.1999_4121
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