Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2020

Abstract

Allergic Rhinitis/Asthma # 01 Hot spots for pediatric asthma emergency department visits in Ottawa, Canada Falana Sheriff1,2, Amisha Agarwal3, Madhura Thipse3, Dhenuka Radhakrishnan2,3,4 1McMaster University, Hamilton, ON, Canada; 2Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada; 3Children’s Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada; 4ICES, Toronto, ON, Canada Correspondence: Falana Sheriff Allergy Asthma Clin Immunol 2021, 17(Suppl 1):01 Background: Pediatric asthma emergency department (ED) visits and repeat visits place a significant burden on healthcare. Monocytes and autologous MDMs incubated with IP-Ig with high sputum aAb titers showed a significant decrease in IL-6, IL-10 and granulocyte macrophage-colony stimulating factor, while monocytes showed reduced interferon-gamma and IL-1b release compared to non-specific IgG controls (p < 0.05, 2-way ANOVA, Tukey’s correction) in response to LPS. Conclusions: We report that presence of sputum aAbs against Mφ proteins, in particular scavenger receptors, could impede effective host defense and lead to recurrent infective bronchitis in eosinophilic asthmatics. #04 Clinical validation of the environmental exposure unit for house dust mite exposure Lubnaa Hossenbaccus1, Lisa M. Steacy2, Terry Walker2, Crystal Malone2, Anne K. Ellis1,2 1Queen’s University, Kingston, ON, Canada; 2KHSC, Kingston General Hospital site, Kingston, ON, Canada Correspondence: Lubnaa Hossenbaccus Allergy Asthma Clin Immunol 2021, 17(Suppl 1):04 Background: The Environmental Exposure Unit (EEU) is a controlled allergen exposure facility used to study allergic rhinitis (AR). Conclusions: The HDM-EEU is a suitable clinical model to induce AR symptoms in HDM-sensitized participants to investigate its symptomatic and biological manifestations. #05 Staphylococcus aureus carriage and biological responses of ragweed pollen-induced allergic rhinitis using the nasal allergen challenge model Sophia Linton1,2, Jenny Thiele1,2, Lisa M. Steacy2, Prameet M. Sheth3,4,5, Anne K. Ellis1,2 1Department of Medicine, Queen’s University, Kingston, ON, Canada; 2Allergy Research Unit, Kingston Health Sciences Centre - KGH Site, Kingston, ON, Canada; 3Department of Pathology and Molecular Sciences, Queen’s University, Kingston, ON, Canada; 4Division of Microbiology, Kingston Health Sciences Centre - KGH Site, Kingston, ON, Canada; 5Gastrointestinal Disease Research Unit, Kingston Health Sciences Centre - KGH Site, Kingston, ON, Canada Correspondence: Sophia Linton Allergy Asthma Clin Immunol