During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online “immuno-analytics” resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid proteins are both vaccine and serological diagnostic targets. Using the tool, the nucleocapsid protein appears to be a sub-optimal target for use in serological platforms. Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased. Also, Orf3a proteins may be a suitable target for serology. The tool can accessed from: http://genomics.lshtm.ac.uk/immuno (online); https://github.com/dan-ward-bio/COVID-immunoanalytics (source code).
CITATION STYLE
Ward, D., Higgins, M., Phelan, J. E., Hibberd, M. L., Campino, S., & Clark, T. G. (2021). An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets. Genome Medicine, 13(1). https://doi.org/10.1186/s13073-020-00822-6
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