Abstract
The POM-1 metallo-β-lactamase is a subclass B3 resident enzyme produced by Pseudomonas otitidis, a pathogen causing otic infections. The enzyme was overproduced in Escherichia coli BL21(DE3), purified by chromatography, and subjected to structural and functional analysis. The purified POM-1 is a tetrameric enzyme of broad substrate specificity with higher catalytic activities with penicillins and carbapenems than with cephalosporins.
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CITATION STYLE
Borgianni, L., De Luca, F., Thaller, M. C., Chong, Y., Rossolini, G. M., & Docquier, J. D. (2015). Biochemical characterization of the POM-1 metallo-β-lactamase from Pseudomonas otitidis. Antimicrobial Agents and Chemotherapy, 59(3), 1755–1758. https://doi.org/10.1128/AAC.03843-14
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