An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles

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Abstract

Minimizing the spread of viruses in the environment is the first defence line when fighting outbreaks and pandemics, but the current COVID-19 pandemic demonstrates how difficult this is on a global scale, particularly in a sustainable and environmentally friendly way. Here we introduce and develop a sustainable and biodegradable antiviral filtration membrane composed of amyloid nanofibrils made from food-grade milk proteins and iron oxyhydroxide nanoparticles synthesized in situ from iron salts by simple pH tuning. Thus, all the membrane components are made of environmentally friendly, non-toxic and widely available materials. The membrane has outstanding efficacy against a broad range of viruses, which include enveloped, non-enveloped, airborne and waterborne viruses, such as SARS-CoV-2, H1N1 (the influenza A virus strain responsible for the swine flu pandemic in 2009) and enterovirus 71 (a non-enveloped virus resistant to harsh conditions, such as highly acidic pH), which highlights a possible role in fighting the current and future viral outbreaks and pandemics.

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Palika, A., Armanious, A., Rahimi, A., Medaglia, C., Gasbarri, M., Handschin, S., … Mezzenga, R. (2021). An antiviral trap made of protein nanofibrils and iron oxyhydroxide nanoparticles. Nature Nanotechnology, 16(8), 918–925. https://doi.org/10.1038/s41565-021-00920-5

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