End-to-end continuous manufacturing of pharmaceuticals: Integrated synthesis, purification, and final dosage formation

Abstract

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.