A Novel Trench FinFET as a Biosensor for Early Detection of Alzheimer’s Disease

Abstract

Presented here we propose and simulate a novel Trenched FinFET biosensor, which may be used as a basis for the diagnosis of Alzheimer’s disease based on their protein marker protein (β-amyloid peptide/protein). The concentration of the β-amyloid peptide in the cerebrospinal fluid is a major indicator of the diseases progression, and by detecting the presence of β-amyloid peptides early on may provide earlier detection and management of Alzheimer’s disease. The device is based on the changes in the dielectric properties of the trench in the presence of β-amyloid peptide. APTES ((3-Aminopropyl) triethoxysilane) is used to bind the β-amyloid peptide to the trench in the device. All comparisons regarding the change of the electrical behavior of the device have been made with air as a reference. A shift in the threshold voltage (Vth) is observed in the presence of the β-amyloid peptide and increases from 0.392 to 0.616 V with the increase in its dielectric constant. Similarly, it is also found that the change in the switching ratio (Ion/Ioff) is also significant and follows an increasing trend from 26.74 to 1.46 × 104 with the dielectric constant. The Ids rises from 3.64 × 10−4A to 4.98 × 10−4A in the presence of β-amyloid peptide. Thus this device can be used as a potential biosensor for the detection of Alzheimer’s disease