Peptide–drug conjugates (PDCs) are being developed for the targeted delivery of drugs to cancer cells. Several approaches are being followed to enhance their stability in biological solutions. Here we describe an effective method to easily couple PDCs to polyethylene-coated gold nanoparticles. We also outline analytical methods to validate the coupling and assays to measure the stability and cytotoxic efficacy of the conjugates.
CITATION STYLE
Kalishwaralal, K., Luboshits, G., & Firer, M. A. (2020). Synthesis of Gold Nanoparticle: Peptide–Drug Conjugates for Targeted Drug Delivery. In Methods in Molecular Biology (Vol. 2059, pp. 145–154). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9798-5_6
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