Abstract
We have identified three novel members of the DPIV gene family using database mining approaches. Recombinant DP8 shares a post-proline dipeptidyl aminopeptidase activity with the closely related enzymes DPIV and FAP. The similarities between DP8, DP9 and DPIV in tissue expression pattern suggest a potential role for DP8 and DP9 in liver disease, T cell activation and immune function. The role of the two novel enzymes DP8 and DP9 and the other non-enzyme member DPL2 in human disease will be the focus of further studies.
Cite
CITATION STYLE
Chen, T., Ajami, K., McCaughan, G. W., Gorrell, M. D., & Abbott, C. A. (2005). Dipeptidyl Peptidase IV Gene Family. In Dipeptidyl Aminopeptidases in Health and Disease (pp. 79–86). Kluwer Academic Publishers. https://doi.org/10.1007/0-306-47920-6_10
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
