Soluble mannose receptor: A potential biomarker in Gaucher disease

Abstract

Purpose: Soluble mannose receptor (sMR) relates to mannose receptor expression on macrophages, and is elevated in inflammatory disorders. Gaucher disease (GD) has altered macrophage function and utilises mannose receptors for enzyme replacement therapy (ERT) endocytosis. sMR has not previously been studied in GD. Methods: sMR was measured by ELISA and correlated with GD clinical features including spleen and liver volume, haemoglobin and platelet count, bone marrow burden (BMB) scores and immunoglobulin levels. sMR was compared with biomarkers of GD: chitotriosidase, lyso-GL1, PARC, CCL3, CCL4, osteoactivin, serum ACE and ferritin. Results: Median sMR in untreated GD patients was 303.0 ng/mL compared to post-treatment 190.9 ng/mL (p =.02) and healthy controls 202 ng/mL. Median sMR correlated with median spleen volume 455 mL (r =.70, p =.04), liver volume 2025 mL (r =.64, p =.04), BMB 7 (r =.8, p =.03), IgA 1.9 g/L (r =.54, p =.036), IgG 9.2 g/L (r =.57, p =.027), IgM 1.45 g/L (r =.86, p