Control of the macromolecular architecture is essential to enable sophisticated functions for glycopolymers and to allow a precise correlation between these functions and the polymer structure. A number of biologically important ligands are negatively charged oligosaccharides that are difficult to manipulate in organic solvent and that are hardly amenable to protection/deprotection strategies. RAFT polymerization is a simple and robust technique that enables the synthesis of well-defined glycopolymers directly in aqueous solution and starting from unprotected vinyl glycomonomers. Here I describe how RAFT polymerization can be combined with reductive amination to transform negatively charged oligosaccharides having 5–20 monosaccharide units into well-defined glycopolymers directly in water and without the need to resort to protecting-group chemistry.
CITATION STYLE
Albertin, L. (2016). Protecting-group-free synthesis of well-defined glycopolymers featuring negatively charged oligosaccharides. In Methods in Molecular Biology (Vol. 1367, pp. 13–28). Humana Press Inc. https://doi.org/10.1007/978-1-4939-3130-9_2
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