Regulation of the X chromosomes in Caenorhabditis elegans

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Abstract

Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences. © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.

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Strome, S., Kelly, W. G., Ercan, S., & Lieb, J. D. (2014). Regulation of the X chromosomes in Caenorhabditis elegans. Cold Spring Harbor Perspectives in Biology, 6(3). https://doi.org/10.1101/cshperspect.a018366

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