Application of P-Bridged Biaryl Phosphines in Pd-Catalyzed α-Arylation Reactions

Abstract

The use of catalysts derived from Pd2(dba)3 and phosphatrioxa-adamantane framework (Cg) has been demonstrated to facilitate the effective alpha(α)-arylation of ketones using a diverse array of aryl halides under mild reaction conditions (40 °C–80 °C). The evaluation of phosphines with dissimilar stereoelectronic properties revealed the pivotal role of fine-tuning the ligand's steric bulk. In particular, catalysts based on the Cg-biphenyl ligand (1) proved efficient for facile α-arylation of electronically and sterically diverse aryl bromides and chlorides.