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Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance

  • Gibson E
  • Ashley R
  • Kerns R
  • et al.
Springer International Publishing, (2018), 507-529
DOI: 10.1007/978-3-319-78538-7_16
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Abstract

Fluoroquinolones are one of the most widely prescribed classes of broad-spectrum antibacterials currently in clinical use. These drugs kill bacteria by increasing DNA strand breaks generated by the type II topoisomerases, gyrase and topoisomerase IV. Despite the...

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Gibson, E. G., Ashley, R. E., Kerns, R. J., & Osheroff, N. (2018). Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance. In Antimicrobial Resistance in the 21st Century (pp. 507–529). Springer International Publishing. https://doi.org/10.1007/978-3-319-78538-7_16

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