Antimicrobial susceptibility and genetic characteristics of Haemophilus infuenzae isolated from patients with respiratory tract infections between 1987 and 2000, including β-lactamase-negative ampicillin-resistant strains

8Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

The minimum inhibitory concentration (MIC) of five antibiotics and the presence of resistance genes was determined in 163 Haemophilus influenzae isolates collected over 13 years (1987-2000) in four two-yearly sampling periods from patients with respiratory tract infections. The prevalence of ß-lactamase-negative ampicillin-susceptible strains was approximately 80% over the sampling period although fewer strains (65.9%) were recovered in the period 1995-1997. TEM-1 type ß-lactamase-producing strains were less frequent starting at 15.6% and declining to 2.2% in the final sampling period. Low-ß-lactamase-negative ampicillin-resistant (BLNAR) strains were uncommon in 1987-1989 (2.2%), peaked to 19.5% in 1995-1997, but fell back to 11.1% by 2000. Fully BLNAR strains were not detected until the last sampling period (6.7%). The MICs of ampicillin, levofloxacin, cefditoren and ceftriaxone remained stable but there was an eight-fold increase in the MIC of cefdinir over the sampling period. Pulsed-field gel electrophoresis of DNA digests showed that three representative BLNAR strains were genetically distinct and 11 DNA profiles were identified among 17 low-BLNAR strains. These data suggest that the number of genetically altered BLNAR and low-BLNAR strains are increasing in Japan. © 2006 Cambridge University Press.

Cite

CITATION STYLE

APA

Qin, L., Watanabe, H., Asoh, N., Watanabe, K., Oishi, K., Mizota, T., & Nagatake, T. (2007). Antimicrobial susceptibility and genetic characteristics of Haemophilus infuenzae isolated from patients with respiratory tract infections between 1987 and 2000, including β-lactamase-negative ampicillin-resistant strains. Epidemiology and Infection, 135(4), 665–668. https://doi.org/10.1017/S0950268806007023

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free