Distinct effects of the mesenchymal dysplasia gene variant of murine patched-1 protein on canonical and non-canonical hedgehog signaling pathways

Abstract

Background: Patched-1 is the primary ligand receptor in both canonical and non-canonical Hedgehog signaling. Results: Truncation of the Patched-1 C terminus impairs regulation of Patched-1-mediated c-src activation and elevates the expression of Hedgehog target genes. Conclusion: The Ptch1 C terminus is required for mediation of both canonical and non-canonical Hedgehog signaling. Significance: A mutant of Ptch1 differentially regulates canonical and non-canonical Hh signaling pathways.© 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.