Engineering cost function for optimizing coherent control between processes with different nonlinearities

Abstract

It has been known that three-photon absorption of DNA or protein is one of the causes of phototoxicity. Here, we apply coherent control to enhance the contrast between the two-photon absorption of fluorescent label and the three-photon absorption of biomaterial with engineered cost function, leading to effectively reduced three-photon absorption with few loss of valuable two-photon fluorescence.