Synthesis of functionalized indolizines by lewis acid-mediated cyclocondensation of 3-(Pyridin-2-yl)-propiolates with enones

Abstract

Functionalized indolizines were prepared by Lewis acid-catalyzed cyclizations of 3-(pyridin-2-yl)-propiolates with enones. This new type of reaction provides a convenient and regioselective approach to ester-substituted indolizine derivatives which are not readily available by other methods. Based on density function theory (DFT) calculations, a mechanism of the reaction has been suggested. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.