Two cases of anesthetics-induced epileptic seizures: a case report and literature review

Abstract

Background: Anesthetics like propofol have been reported to be capable of controlling status epilepticus. However, we have observed during daily clinical work that some anesthetics can induce epileptic seizures. Therefore, this study aims to explore the relationships between anesthetics and epilepsy. Case presentation: We collect and report two cases of anesthetics-induced epileptic seizures, in order to arouse attention towards this critical phenomenon. We also summarize the current research progress on this topic, analyze associations between anesthetics and epilepsy, and discuss the mechanisms underlying the associations. Two females, seizure-free for more than 3 years, presented with anesthetics-induced epileptic seizures and controlled by administration of Midazolam and Diazepam. By literature review, we included six studies which found that the occurrence of epileptic seizures has no relationship with the age/sex of patients, the surgery procedure, nor the type of anesthesia. It is closely related to the decreased blood concentration of antiepileptic drugs (AEDs) and the inadequate preoperative preparation. Conclusions: Unnecessary surgery should be avoided for patients with epilepsy, and anesthetists should make careful selections on anesthetics and prepare adequately for surgery.