Abstract
Two new antibiotics, CJ-16,264 (I) and CJ-16,367 (II), were isolated from the fermentation broth of an unidentified fungus CL39457. These antibiotics have a pyrrolizidinone skeleton, first discovered in fungi. Compounds I and II inhibit the growth of Gram-positive multi-drug resistant bacteria and some Gram-negative strains such as Moraxella catarrhalis and Escherichia coli with altered permeability (imp). Comparison of an antibacterial profile between the two compounds suggested that the gamma-lactone portion of I is important for the activity.
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CITATION STYLE
Sugie, Y., Hirai, H., Kachi-Tonai, H., Kim, Y. J., Kojima, Y., Shiomi, Y., … Kojima, N. (2001). New pyrrolizidinone antibiotics CJ-16,264 and CJ-16,367. Journal of Antibiotics, 54(11), 917–925. https://doi.org/10.7164/antibiotics.54.917
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