Direct Repression of prdm1 by Bcl-6 Inhibits Plasmacytic Differentiation

  • Tunyaplin C
  • Shaffer A
  • Angelin-Duclos C
  • et al.
309Citations
Citations of this article
162Readers
Mendeley users who have this article in their library.

Abstract

We have identified two intronic regions of mouse prdm1, the gene encoding B lymphocyte-induced maturation protein-1 (Blimp-1), which confer transcriptional repression in response to Bcl-6. The Bcl-6 response element in intron 5, which is conserved between mice and humans, was studied in detail. It binds Bcl-6 in vitro and was shown by chromatin immunoprecipitation to be occupied by Bcl-6 in vivo. Neither Bcl-6 response element functions as a STAT3-response element, showing that STAT3 does not compete with Bcl-6 at these sites. Bcl-6−/− mice confirm the biological importance of Bcl-6-dependent repression of prdm1. These mice have elevated Ab response, increased Ig-secreting cells, and increased Blimp-1+ cells in spleen following immunization and their splenic B cells show accelerated plasmacytic development in vitro.

Cite

CITATION STYLE

APA

Tunyaplin, C., Shaffer, A. L., Angelin-Duclos, C. D., Yu, X., Staudt, L. M., & Calame, K. L. (2004). Direct Repression of prdm1 by Bcl-6 Inhibits Plasmacytic Differentiation. The Journal of Immunology, 173(2), 1158–1165. https://doi.org/10.4049/jimmunol.173.2.1158

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free