Background: Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China. Methods: A total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR. Results: Apolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p∈
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Sun, Y. P., Zhang, B., Miao, L., Wang, X. M., Yu, J. H., Luo, L., … Yao, H. (2015). Association of apolipoprotein e (ApoE) polymorphisms with risk of primary hyperuricemia in Uygur men, Xinjiang, China. Lipids in Health and Disease, 14(1). https://doi.org/10.1186/s12944-015-0025-2
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