Assessment of Corneal Biomechanical Properties by CorVis ST in Patients with Dry Eye and in Healthy Subjects

Abstract

Purpose. To investigate corneal biomechanical properties in patients with dry eye and in healthy subjects using Corneal Visualization Scheimpflug Technology (CorVis ST). Methods. Biomechanical parameters were measured using CorVis ST in 28 eyes of 28 patients with dry eye (dry eye group) and 26 normal subjects (control group). The Schirmer I test value, tear film break-up time (TBUT), and corneal staining score (CSS) were recorded for each eye. Biomechanical properties were compared between the two groups and bivariate correlation analysis was used to assess the relationship between biomechanical parameters and dry eye signs. Results. Only one of the ten biomechanical parameters was significantly different between the two groups. Patients in the dry eye group had significantly lower highest concavity time (HC-Time) (P=0.02) than the control group. Correlation analysis showed a significant negative correlation between HC-Time and CSS with marginal P value (ρ=-0.39, P=0.04) in the dry eye group. Conclusions. The corneal biomechanical parameter of HC-Time is reduced in dry eyes compared to normal eyes. There was also a very weak but significant negative correlation between HC-Time and CSS in the dry eye group, indicating that ocular surface damage can give rise to a more compliant cornea in dry eyes.