The synthesis and biological evaluation of A-ring substituted steroidal p-quinones

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Abstract

The preparation of A-ring steroidal 1,4-quinones involves m-CPBA/(BzO) 2 O/hv oxidation of estrone (or estradiol Ill-acetate), acid rearrangement of the obtained quinol, and oxidation. A detailed NMR analysis of 1,4-quinones and their derivatives, as well as the results of preliminary antibacterial and cytotoxicity tests is presented.

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Milić, D. R., Gašić, M. J., Muster, W., Csanádi, J. J., & Šolaja, B. A. (1997). The synthesis and biological evaluation of A-ring substituted steroidal p-quinones. Tetrahedron, 53(41), 14073–14084. https://doi.org/10.1016/S0040-4020(97)00910-1

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