Coagulopathy, a common complication of traumatic brain injury (TBI), is characterized by a hyperco-agulable state developing immediately after injury, with hyperfibrinolysis and bleeding tendency peak-ing 3 h after injury, followed by fibrinolysis shutdown. Reflecting this timeframe, the coagulation factor fibrinogen is first consumed and then degraded after TBI, its concentration rapidly decreasing by 3 h post-TBI. The fibrinolytic marker D-dimer reaches its maximum concentration at the same time. Hyperfibrinolysis in the acute phase of TBI is associated with poor prognosis via hematoma expan-sion. In the acute phase, the coagulation and fibrinolysis parameters must be monitored to determine the treatment strategy. The combination of D-dimer plasma level at admission and the level of con-sciousness upon arrival at the hospital can be used to predict the patients who will “talk and deterio-rate.” Fibrinogen and D-dimer levels should determine case selection and the amount of fresh frozen plasma required for transfusion. Surgery around 3 h after injury, when fibrinolysis and bleeding dia-thesis peak, should be avoided if possible. In recent years, attempts have been made to estimate the time of injury from the time course of coagulation and fibrinolysis parameter levels, which has been particularly useful in some cases of pediatric abusive head trauma patients.
CITATION STYLE
Nakae, R., Murai, Y., Takayama, Y., Namatame, K., Matsumoto, Y., Kanaya, T., … Yokobori, S. (2022). Neurointensive Care of Traumatic Brain Injury Patients Based on Coagulation and Fibrinolytic Parameter Monitoring. Neurologia Medico-Chirurgica, 62(12), 535–541. https://doi.org/10.2176/jns-nmc.2022-0226
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